Worn out with the employment of all types and combinations of drugs researchers are concentrating on the Mother Nature machineries to beat the various illness. Recently researchers trying to use necrosis natural programmed cell death as a device to vanish the cancerous cells. MIT researchers may offered an approach, they identified a key protein in alternative death pathway i.e necrosis. Apoptosis is a tightly controlled program that breaks down and disposes of the dying cell, It is a hectic process in which the cell’s membrane ruptures and its stuffs splash out. Previously it was thought this necrosis process occurs independent of gene products, but constant studies on it prove that this is a energetic process & involves a sequential proteins coded by the genome of cell.
ALKBH7 is a major protein in necrosis. Proteins ALKBH7 first revealed in E. coli few years ago as part of a DNA-repair mechanism. In humans, there are nine different ALKBH proteins also involved in DNA repair especially when alkylating agents are involved. ALKBH7 has a sudden & sharp effect, when the cells cultures have less amounts of this protein the cells shown survival with the damaged DNA when compared with normal cells. This shows that this protein put to death to cells. The spilled out contents of cells will attract macrophages and alters the body system against infection. In some cases this is also initiated by the viral/bacterial infection.
In this way this findings suggest that when cells suffer from more amounts of DNA damages then necrosis put the boot and protect the cells by becoming more cancerous.So pathway is initiated by an enzyme called PARP, and becomes hyperactive by DNA damage and close down the cell’s production of crucial molecules that carry energy i.e ATP and NAD. The MIT team found that ALKBH7 prevents ATP and NAD levels from returning to normal by disrupting the function of mitochondria which is energy factory for cells, the inadequate supply of energy molecules lead to the death of cell by it.
The researchers are now examining the molecular details of the programmed necrosis pathway in hopes of identifying ways to set in motion cancer cells which in turn put to end of them.Tags: cancer cells, Genome, Necrosis