Spperm aneuploidy is genetically abnormal condition of serms. These abnormalities are due to the errors occurs during meiosis. Usually chromosomal abnormalities are detected by karyotype analysis. But the majority of sperm chromosomal abnormalities cannot be detected by the above method. A major problem with which couples are suffering is infertility. Sperm abnormality is one of the main causes for infertility. Some of the causes for sperm aneuploidy are cigarette smoking, alcohol, caffiene, advanced age, exposure to radiation, chemotherapy etc. Treatment options for sperm aneuploidy can be decided by sperm aneuploidy screening. The recent technique for sperm aneuploidy testing is fluorescent in situ hybridization (FISH). Male patients who have problems like unexplained infertility, oligoasthenoteratozoospermia, recurrent miscarriage in partner may get benefits from this technique.
Fluorescence in situ hybridization analysis is performed with chromosome specific DNA probes labeled with fluorochromes. It is a simple and reliable tool for the oblique study of aneuploidies in spermatozoa. Five to seven chromosomes are evaluated in individual ejaculates to decide the percent of aneuploid sperm present. The limitation for this technique is only 5 probes can be used routinely for the analysis.

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