Carbohydrates are the building blocks of molecular biology. According to Ajit P. Varki of the University of California,Carbohydrates in molecular biology are like dark matter in the universe. Carbohydrates has led to the development of rapid synthesis, sequencing, and bioinformatic methods for DNA and proteins gave scope for genomics and proteomics to flourish.These carbohydrates are said to be the mainstream areas of material science and biofuels.Almost all the mammalian proteins are glyco¬sylated. Glycans or the oligosaccharides on these proteins acts as a source of the recognition sites for many protein-receptor and cell-cell interactions. Glycans play a vital role as they are directly involved in the etiology of every human disease. To understand and treat disease and to exploit glycans for fuel and materials, it becomes a primary responsibility to concentrate on glycosciences. Prior importance should be given towards the study of a number of subdisciplines of carbohydrate research.
According to a carbohydrate chemist Chi-Huey Wong, president of Academia Sinica, in Taipei, Taiwan modified specific glycan on a glyco¬protein can help us to understand the effect of that glycans structure and function of the glycoprotein, and also to make glycoproteins with optimal activity” for potential drug applications. A new centralized database of mammalian, plant, and microbial carbohydrates and glycoconjugates that is fully integrated with DNA and protein databases can be created which would help us in understanding the function of glycoproteins.
Tags: Human Disease, Material Science, Molecular Biology