The common known diseases of heart and metabolism are found to be genetically more complex in respect to associated epigenetics and environmental factors. The underlined genetic co-expression which influences multiple active nucleotide sequences is said to be the known cause. Unlike based on the classical genetics principles stating one or few genes in the same genome sequence, these complexity studies have proved the necessicity of genetic pathways and network analysis studies to be involved in genetic interpretations. Supporting proving involve genetic polymorphisms shown by point mutations in the genome ie SNPs, functional relativity associated within the gene families as well as protein families, natural selection has just silent the virulent gene expression but has not removed it in human population, environmental influencers of genetic expression have their vital role of more than 2/3rd.

Defining variants have given common and rare as classification which are intermixed in a definite proportion giving rise to a genetic expression signature; this nucleotide expression set is specific to an individual. The classified variants share an expression ratio where in one rare variant is found for every three commons. In a step to simplifying this complexity common, the pre-transcriptomic sequences were compared with that of post-transcriptomic expression sets; special sequences like promoters and enhancers have once again proved their unconditional importance. The genetic  disorders and disease portfolio has relied on the whole but personalized genome sequencing for individual’s therapy.

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