In the condition of co-infection of HIV and Hepatitis, increases the risk of impairment and neurocognition. This is proved by the research done by the one of the U.S.A research department, which is show the result of mono infected HIV and Hepatitis person and co-infected person of HIV and Hepatitis C. In case of neurocognition there is a risk of neuropsychological impairment it is shows that the there is some link between the infection with the hepatitis C virus may be associated with a degree of neurocognitive decline, HIV-related neurocognitive dysfunction can range from subtle deficits in information-processing speed and efficiency to a pronounced dementia syndrome. The neurocognitive consequences of AIDS and HIV neuropsychiatric features are like depression, apathy and irritability are repeatedly or constantly present among infected individuals. That is shows clearly like psychiatric symptoms for Example depression, anxiety, apathy, irritability and among HIV-infected individuals is not always a consequence of central nervous system disturbance. Measure of cognitive impairment and neurocognition is by the help of neurocognitive diagnosis and Psychiatric diagnosis. In the most recent study of co-infection is found the high level of T-cell activation in co-infected compared to HIV mono infected individual even following highly active antiretroviral therapy. In case of chronic immune activation may lead to immune dysfunction and also cytokine production which is cause and increases the HIV and HCV replication and lower T-cell count. In some of the pathway for activation of HCV infection impact the HIV infection has been proposed and HCV co-infection may increase immune activation and leading to CD4 T-cell apoptosis in HIV-untreated patients and which is cause the more rapid progression to severe immunodeficiency .

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