Neurological Disease to be Treated by Modulating Epigenetic HAT Activity
Three-dimensional structure of chromatin is demarcated by the epigenome with its rich reserve of greatly directed structural changes to the DNA, histone buildups and histone variants which serves s the sub-atomic scaffold between transcriptional gene control and our surroundings.Gene misregulation that drives cognitive decay and memory weakness which is brought about by experience identified aggregation of unusual epigenetic checks in chromatin in the grown-up mind as prescribed by late speculation. Alzheimer’s disease has in addition been reported in numerous considers by lessened histone acetylation in animal models of neuro degeneration that show cognitive deterioration.
Efficacy of directly activating specific HAT function as a new and more selective epigenetic based therapy for cognitive disorders is shown by increasing understanding of specific HATs and their respective roles in memory formation and neuronal function. These are emerging as regulators that regulates access to genes regulating specific neuronal processes which are essential for maintaining neuronal health and for mediating higher order brain functions.
Presence of specific modulators can have more direct effects so targeting HATs can also be beneficial because unlike HDACs, HATs have non-redundant functions under physiological conditions. development of novel drugs and specific therapeutic strategies with lower adverse side effects can be facilitated by determining the genes or “cassettes” of genes that are regulated by such HATs and characterizing the survival or degenerative effects.