Mitochondria are small organelles found in most of the cells. Each cell consists of 100 up to 3000 in each cell. Mitochondria are described as cellular power houses because they generate adenosine triphosphate (ATP) which is a is a high energy source of chemical energy. Many agents involved in mitochondria dysfunction they include including environmental toxins, heavy metals, excess iron (haemocromatosis), pesticides, chronic bacterial, viral and fungal infections and neurotoxins. Nutrient deficiencies like uncured oil process . Toxic elements involved in the enzyme binding sites which acts by modifying binding sites. Mitochondrial dysfunction can be detected by doing a urinary organic acids test. Many times mitochondria dysfunction is caused by impaired energy production in cell. Treatment for mitochondria dysfunction involves removing the antagonize agent such as infection or toxin This involve the use of medications or nutritional agents to destroy any infection whether it is bacterial, viral, parasitic or fungal and also detoxification of heavy metals. Control hormone deficiencies imbalances such as thyroid and/or adrenal hormones which help regulate the citric acid cycle. Dietary and lifestyle intervention is important to reduce oxidative stress. This involves removing dietary antigens which can trigger oxidative damage, in addition to this exposure to environmental toxins, pollution, smoke, stress etc also need to be eliminated. Supplement of mitochondria with all the nutrients, substrates and cofactors required for the citric acid to occur, along these antioxidants are also required to prevent further oxidation of the mitochondria.